Nine herbicides such as cyclosulfone need to add safety agents before use

With the increasing efforts of the state to strengthen the quality and safety of agricultural products, agricultural and forestry production and ecological environmental protection, the quality requirements for pesticide products are becoming increasingly strict. In addition to the effective ingredients, the banned additives and special function additives such as safety agents, stabilizers, synergists are also strictly managed. It is necessary to provide information on their quality specifications, basic physical and chemical properties, sources and safety, domestic and foreign use, etc., to ensure that in addition to the active ingredients, the additive ingredients in pesticide products will not adversely affect human and animal health and the ecological environment. It can be seen that special functional auxiliaries such as safety agents also need to be clarified in product composition, standards and other registration data, which has a crucial role in whether the product can successfully pass the approval. Now the author of the relevant knowledge of the safety agent is sorted out as follows, hoping to provide a reference for the majority of enterprises in the product registration process.

1 What is a safety agent

safener, also known as antidote or protectant, is a chemical substance with unique properties. Safety agent is to selectively protect crops from herbicide damage without affecting the activity of the effective ingredient of herbicide on the target weed, so as to enhance the tolerance of crops to herbicides and increase the safety of herbicides on crops. The addition of safety agents to herbicides is a means of artificially giving herbicides selectivity, and its role also includes selective synergistic herbicides to expand the herbicide's herbicide spectrum without increasing the damage to crops.

2. Purpose and significance of adding safety agents to pesticides

Some herbicide varieties have remarkable control effect on weeds in certain crops, but due to the poor metabolic detoxification ability of crops, the selectivity of these herbicide varieties is poor. Direct application on crops will cause leaf yellowing, chlorosis, deformity, shrinkage, plant dwarfing and other harmful symptoms, which will affect the normal growth of crops, and lead to a significant decline in yield in severe cases. Cause great economic loss. Therefore, the addition of safety agents helps to improve the safety of crops and is one of the important measures to ensure the bumper harvest of crops.

In addition, due to the irrational use of pesticides in agricultural production, weed resistance is becoming increasingly serious. It is necessary to develop new excellent herbicide varieties with unique mechanism of action and use them alternately or mixed with conventional herbicides in production to reasonably control weed resistance. The addition of appropriate safety agents can help overcome the application bottleneck of poor safety of excellent varieties, so that some chemical herbicides with high performance can be widely used. The practice of adding safety agents to herbicides paves the way for the development of new herbicides, allowing more herbicide products to be applied and expand the marketing market.

3 Which products need safety agents to be added before use

According to the accumulation of daily work, the author suggests that the following herbicides should be used with corresponding safety agents to ensure the effectiveness of their use and the safety of crops.

(1) Oxynol: oxynol is an aryl oxyphenoxypropionate herbicide developed by Novartis (now Syngenta) in 1990. Used for stem and leaf spray control of annual grass weeds in cereal crops such as wheat. When used in practice, it is generally necessary to use with the safety agent Cloquin (detoxoquine, cloquintocet-mexyl).

(2) Zolinoxate: Zolinoxate is a phenyl pyrazoline herbicide developed by Syngenta in 2006. Used for stalk and leaf spray control of annual grass weeds in wheat fields and barley fields. When used in practice, it is generally necessary to use with the safety agent Cloquin (detoxoquine, cloquintocet-mexyl).

(3) Fenoxazoline: Fenoxoline is an aryl oxyphenoxypropionate herbicide developed by Hearst (now Bayer) in 1988. Can be used for stem and leaf spray control of annual and perennial grass weeds in potato, bean, beet, vegetable, peanut, flax, rape and cotton fields. When used in wheat, barley and other grain fields, it is generally necessary to use the safety agent mefenpyr-diethyl or fenchlorazole-ethyl.

(4) Methyldisulsulfuron: Methyldisulsulfuron is a sulfonylurea herbicide developed by Aventis (now Bayer) in 1996. It can be used for stalk and leaf spray to control annual grass weeds and some broad-leaved weeds in wheat, black wheat and other grain fields. When used in practice, it is generally necessary to use with the safety agent mefenpyr-diethyl.

(5) Propachlor: Propachlor is a chloroacetamide herbicide developed by Ciba-Gaigi (now Syngenta) in Switzerland in 1998. It can be used to control annual grass weeds, broad-leaved weeds and sedges in rice transplanting and direct seeding fields. When used in rice field, it is generally necessary to use with the safety agent fenclorim.

(6) Formamidosulfuron: Formamidosulfuron is a sulfonylurea herbicide developed by Aventis (now Bayer) in 1995. It can be used for stem and leaf spray to control annual grasses and broad-leaved weeds in corn fields. When used in practice, it is generally necessary to use with the safety agent isoxadifen-ethyl.

(7) Cyclosulfosterone: cyclosulfosterone is a new triketone corn herbicide developed by Bayer in 2007, which can be used for stem and leaf spray to control annual grasses and broad-leaved weeds in corn fields. Its control spectrum and activity are higher than that of nitrosulfamone, which maintains good herbicidal activity in the whole growth period of crops and has strong resistance to rain erosion, and has been registered in many countries in the world. Since its listing, market sales have continued to grow, with global sales of $240 million in 2014, making it one of the top 10 pesticide varieties in Bayer's 2014 sales. In the next few years, its market is more worthy of expectation, and it is worth paying attention to. For practical use, it is usually used in combination with the safety agent isoxadifen-ethyl or cyprosulfamide.

(8) Isoxazolidone: Isoxazolidone is an isoxazole herbicide developed by Rhone-Planck (now Bayer) in 1992. It is mainly used for pre-seedling soil treatment to control annual grasses and broad-leaved weeds in corn and sugarcane fields. When used in practice, it is generally necessary to use with the safety agent cyprosulfamide.

(9) Methyl iodosulfuron Sodium salt: Methyl iodosulfuron sodium salt is a sulfonylurea herbicide developed by Egford (now Bayer) in 1999. It can be used for stem and leaf spray treatment to control annual grasses and broad-leaved weeds in wheat, barley and other grain fields. When used in practice, it is generally necessary to use with the safety agent mefenpyr-diethyl.

It should be noted that the safety agent of the above pesticide active ingredients is not unchanged, and a variety of safety agents may be selected for the same active ingredient, and newer, better and more excellent safety agents may also emerge with social development and technological progress.

The above content is based on the summary of actual work experience. It is hoped that all enterprises will pay attention to the registration matters such as starting product registration, configuring test samples, arranging registration tests, and preparing registration materials, so as to improve the passing rate of product registration. In particular, we remind enterprises to avoid unnecessary trouble to themselves, in the production of related products, according to the composition of the registration application, add safety agents to the relevant products, so that they are responsible for themselves and responsible for the users.